Role of Endothelial cell in the control of adipose tissue function

Contact Name for applications: Elena Osto

Email: elena.osto@uzh.ch

Phone: +41432533098

Country: Switzerland

City: Zurich

Institution: Cardiology Department & institute for clinical Chemistry

Title of Position: Post -Doctoral position

Summary of Position: Crosstalk between endothelial cells and adipocytes in cardio-metabolic diseases

Full Details of the Post ( English only ):

We are hiring! A post-Doctoral position is available in the group of Prof. Elena OSTO's cardio-metabolic research at the University of Zurich

https://www.cardiometabolicresearch.com/

http://www.en.ikc.usz.ch/research/Pages/Vascular-Biology.aspx

Your profile:

We are looking for a highly motivated:

• Post-Doc candidate with a PhD, MD or MD/PhD degree

with a strong background in cardiovascular (endothelial or vascular biology) and/or metabolic disease (obesity and in particular adipocyte biology). The project of the newly hired post-Doc focuses on how blood vessels and adipocytes metabolically crosstalk in health and obesity. Qualified applicants should have a strong record of achievements as evidenced by first-author research papers published in peer-reviewed journals and have a strong interest in a multidisciplinary approach to experimental and clinical research. The ideal candidate shows initiative, a vigorous “Can-Do“-mentality and ambition to succeed in a research career. The candidate is reliable and well organized and shows social skills to work in an international team. Hands-on experience with cardiovascular/metabolic animal models is required (FELASA recognized e.g., metabolic phenotyping of rodent model of obesity, diabetes, genetically modified strains; surgical skills are a plus). Laboratory techniques will include flow cytometry, Seahorse measurements,endothelial cell isolation, single cell RNA sequencing, myograph vascular studies, advanced imaging techniques, i.e. echocardiography. Prior experience on primary endothelial and adipocytes research are of clear advantage. The ability to design, evaluate and report research is required as well as excellent verbal and written communication skills in English.

The project:

Our SNSF-funded lab uses a combination of state of the art molecular techniques to complement mouse and human models of disease. The dysfunction of endothelial cells is a key player in cardiovascular and metabolic disease. However, the molecular mechanisms that disrupt endothelial homeostasis remain unclear. We examine the crosstalk between gut hormones (i.e. glucagon-like peptide-1, bile acids), adipocytes and endothelial cells in health and disease. Samples collected from animal models or patients with obesity, type 2 diabetes and after bariatric surgery or other types of weight loss treatments will be analyzed in parallel. Previous experience with laboratory rodents is mandatory.

This position requires a direct involvement in the experimental and clinical arms of the study and close interaction/supervision of Master and PhD students.

Start: Immediately available.

Please send your complete application material, including cover letter, CV, statement of motivation, list of publications, and of 2 contacts for reference combined into one single PDF-file to: elena.osto@uzh.ch